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Phosphorylation of serine, threonine, or tyrosine converts a neutral hydroxyl into a phosphoester carrying approximately two negative charges at physiological pH, a dramatic change in charge state that underlies much of cellular signaling logic

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As a small molecule that mimics and potentiates HGF activity while maintaining oral bioavailability and blood-brain barrier penetration, Dihexa offers practical advantages over gene therapy or protein-based approaches for clinical translation
