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Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation,S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation

Metabolic disorder

Decreases in glutathione synthesis and tissue concentrations can reduce the bodys ability to deal with oxidative stress, but research shows that lipoic acid may enhance the synthesis of GSH via upregulating expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme involved in its production, but also by increasing cellular uptake of cysteine, a precursor amino acid required for GSH synthesis

[7] Lauterburg, B.H., Adams, J.D