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These calculi occur primarily because cystine is one of the least water soluble amino acids and as such is more likely to precipitate in target organs
10 GPX4 inhibitors can be used as senolytics in one-two-punch anticancer therapies in an ovarian cancer model
10.1016/S0021-9258(19)50212-5 67
On another hand, where IKE + DHAA is a potent inducer of ferroptosis, it is tempting to speculate that IKE + DHAA is rapidly depleting GSH, favoring strong GPX4 inactivation
