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Ammonia is a toxic byproduct of protein metabolism that accumulates in the body and causes cellular damage

When administered to insulin-resistant, middle-aged obese rhesus monkeys, GW501516 leads to a substantial dose-dependent increase in serum high-density lipoprotein cholesterol, alongside reductions in small-dense low-density lipoprotein, fasting triglycerides, and fasting insulin levels

PRS, polygenic risk score

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