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Rizza et al., Reference Rizza, Walia, Tang and Jones2019)

First, FOXO4 localizes predominantly in the cytoplasm of normal Leydig cells, as shown by both our in vitro and in vivo findings, while it is within the nucleus that FOXO4-DRI interferes with the FOXO4-p53 interaction [24]

For those who are deficient, it may be necessary to supplement the diet with B12

Functionally analogous are the Peroxiredoxins (Prx) , which use the same mechanism but with a cysteine active site that shuttles from the thiolate (S-H) to the sulphinic acid (S-OH) form and is reduced back by glutathione
