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Furthermore, miR-137 levels were negatively correlated with YB-1 levels, and YB-1 and IGF1R were positively correlated ( Among the deregulated miRNAs in CRC, also miR-532 had a tumor-suppressive role ( in vitro , while reduced tumor growth was observed in vivo ( in vitro and in vivo ( The let-7 family has been reported to be downregulated in many types of cancer, including CRC ( Several studies have provided sufficient evidence that miR-9 also participates in colorectal tumorigenesis acting as a tumor suppressor ( The newly discovered GATA4-miR1 was located in the second intron of the GATA4 gene, which belongs to a transcription factor family involved in carcinogenesis ( A recent review summarized a number of miRNAs related with IGF2 regulation in CRC ( in vitro and reduced growth velocity and weight of tumors and tumor nodule formation in vivo

10.1016/j.neuron.2014.01.013 118 FreischmidtA.WielandT.RichterB.RufW.SchaefferV.MullerK.et al

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Their presence in the formulation is valued for promoting a well-balanced nutritional intake