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Deficiencies can be observed more frequently, with older persons as well as vegetarians and especially vegans representing risk groups (Shipton and Thachil, 2015)
If you experience symptoms of those side effects, talk to your doctor immediately

doi: 10.5415/apallergy.0000000000000022

These prescribing patterns were noted in patients without specific contraindications, though opioids were seen more in patients with a history of gastroesophageal reflux