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Different receptor binding profiles, different pharmacokinetics, different dose-response curves

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The formulation isn't arbitrary

Revised Nov 2017 Side Effects for Caverject The following are described elsewhere in the labeling: Prolonged Erection and Priapism [see WARNINGS AND PRECAUTIONS ] Penile Fibrosis [see WARNINGS AND PRECAUTIONS ] Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice