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Med 15, 206210 (2009)

NNMT inhibition in cell culture models has been associated with enhanced myogenic commitment, suggesting that the same NAD+/SAM preservation mechanism that restores adipocyte energy expenditure may also support muscle regeneration processes

23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

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