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However, a critical appraisal of this evidence is imperative, particularly for distinguishing robust, specific mechanisms from potential artifacts associated with PAINS prevalent in its phytochemical profile ( in vitro findings requires careful evaluation alongside in vivo and clinical data to establish a mechanistic foundation for evidence-based clinical implementation

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Emerging evidence suggests that the activation of the gut-brain axis through intestinal inflammation may contribute to PD pathogenesis, with gastrointestinal dysfunction representing the most common non-motor symptom (Zhong et al., 2022

GPx relies on glutathione (GSH), a tripeptide that donates electrons to reduce peroxides and counteract ROS, effectively preventing oxidative damage