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Description
According to the US Food and Drug Administration (FDA), more than 90% of neuroprotective drugs tested at the clinical level to treat central nervous system (CNS) diseases have not been approved due to their poor bioavailability [27]

Of interest, while the actions of IGF-I after birth are being continuously recognized, the physiologic role of IGF-II is still poorly understood at this stage[1, 30]
Mosawi A Al (2021) A novel therapeutic approach for treating rett syndrome
Vitamin B12 As a diagnosed Pernicious Anaemia patient of 6 years , I do not advise you to use nasal spray instead of B12 injections