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Juxtacrine regulation of cellular senescence
The lack of a beneficial effect of selenium supplementation was supported in a 2014 meta-analysis of randomized controlled trials (67)
These should include: (1) Examination of these processes at different stages of the disease, (2) mechanistic studies to pinpoint signaling pathways involved in the regulation of the oxidative stress and DNA damage response markers and (3) studies addressing whether the deficits reported here can be reverted with antioxidant treatments
