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These findings demonstrate that NRF2 activity may serve as both a clinical biomarker as well as an actionable therapeutic target
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Neuron apoptosis pathway Prolonged OHP exposure induces the phosphoprotein 38 (p38) and extracellular regulated kinase 1/2 (ERK1/2) early activation, which promotes the apoptosis of DRG neurons, and the down-regulation of protective c-JunNH2-terminal kinase /stress activated protein kinase (JNK/Sapk), which increase OHP neurotoxic effects in vitro [96, 134]

10.1016/j.bbrep.2020.100834 94 OakleyA
