acetyl-l-carnitine diabetic neuropathy rct doi Targeting Oxidative Stress and Mitochondrial Dysfunction in Neuropathy: Mechanisms and Therapeutic Opportunities acetyl-l-carnitine diabetic neuropathy rct doi
Description
PDHA1 knockout mice (bKO) display glucose intolerance and markedly reduced pancreatic secretion but no decrease in insulin sensitivity (148), indicating that hyperglycemia in bKO mice results from -cell dysfunction and insulin secretion imbalance rather than peripheral tissue insulin resistance
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
In some embodiments, the loss is caused by a brain injury, e.g
Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD
