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The intramuscular route ensures consistent, reliable delivery of B12, independent of gastrointestinal absorption

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Additionally, the overall quality of evidence for each outcome was evaluated using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework ( As this systematic review did not involve meta-analysis due to the heterogeneity of study designs, intervention protocols, and outcome measures, data were synthesized using a qualitative narrative synthesis approach

When these are used, the description of the medication and dosage should be indicated in box 24a of the CMS-1500 form or EDI loop 2410