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As, in a mouse model of gastric cancer, lipid aggregation in tumor-associated macrophages (TAMs) upregulated the expression of phosphoinositide 3-kinase (PI3K-) and promoted TAM polarization to the M2 phenotype
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The company submitted a New Drug Application to the United States Food and Drug Administration in December 2025, based on the REDEFINE 1 and REDEFINE 2 results, with a decision anticipated late in 2026

This stability allows for different BPC-157 delivery methods that arent possible with other peptides
