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3.1.3 Metabolic modulators 3.1.3.1 Classical metabolic modulators These drugs adjust the substrate utilization or metabolic pathways of immune cells

Cell-penetrating peptides (CPPs) are short amino acid sequences that traverse cell membranes to deliver bioactive molecules intracellularly [8,9,10]

Oxymatrine attenuates dopaminergic neuronal damage and microglia-mediated neuroinflammation through cathepsin D-dependent HMGB1/TLR4/NF-B pathway in Parkinsons disease

After completion of biosynthesis, secondary metabolites like GSLs and flavonoids, which are present at high concentrations in the cell, need to be imported into the vacuole ( Figure 2 , the identity is unknown), stored there or further metabolized and/or transported ( Figure 3 , transporters 16 and 17)