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A deficiency in Gclc (encoding a glutamate cysteine ligase) affects major metabolic regulators, such as mTOR, NFAT, and c-Myc

This, in turn, affects lipid metabolism and inflammatory responses

28,29 Vitamin B 6 serves as a cofactor to more than 140 enzymes, it is required for tryptophan metabolism and synthesis of nicotinic acid, and it is a cofactor for alanine aminotransferase and aspartate aminotransferase

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