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Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020
Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron
The likely mechanism by which A 142 induces HSV-1 aggregation is by the shared sequence homology of an aggregation-prone region of the HSV-1 glycoprotein B to which A 142 can bind and induce aggregation (Cribbs et al., 2000)
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