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Characteristic pattern of free amino acids in plasma and skeletal muscle in stable hepatic cirrhosis

10.1093/hmg/ddw045 357 YunJ.MullarkyE.LuC.BoschK

Thus, one can speculate that RBC uptake and consumption of methyl-group donors (e.g., methionine, choline) could compete with other tissues where these substrates are used to fuel epigenetic regulatory mechanisms, such as methylation of proteins (e.g., histones), RNA (N6-methyladenosine) and DNA (CpG islands), making RBCs an indirect player in systemic long-term responses to oxidant stress events

Further modifications, including solubility-enhancing groups, led to UAMC-3203, which demonstrated superior potency, stability, and solubility, with no toxicity in mouse models (Devisscher et al., 2018)