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The penetration boost is backed by lab research: studies using human skin samples found it improved how well an active dissolves into the upper layer of skin rather than tearing down your skin barrier

doi: 10.3390/cancers15184533 82 ZhangGGuoCWangYZhangXLiuSQuWet al
We recommend drinking 16-20 ounces of water 2-3 hours before treatment

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