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The acyl-CoA then undergoes -oxidation, with each cycle producing acetyl-CoA (for the TCA cycle), FADH, and NADH, ultimately driving ATP synthesis via oxidative phosphorylation [35]

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Experimental data shows that macrophages treated with TMAO can significantly increase the expression levels of IFN-, Ki-67, CD103, and CD44 in CD8 + and CD4 + T cells, indicating enhanced T cell activation and proliferation