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Similarly high incidence has been recently reported in Chinese provinces south of the Yangtze River (Figure 2), including Guangdong, Fujian, Hunan, Shanghai and Xuzhou in Zhejiang.7-10 In fact, the highest incidence of CUD may be in Fujian at around 1 in 10,000 newborns.9 On the other hand, incidence was lower in Northern China, like Shangdong.11 The high disease incidence in this locality is due to common mutations

Higher concentrations of EGCG (up to 100 M) inhibited autophagy, leading to apoptosis in macrophagecelllines [170] and cancer cells [180]

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