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This stable pool of mVEGFR1 constitutively internalizes and likely recycles, allowing endothelial cells to rapidly modulate VEGF-A signalling cell-autonomously, without de novo protein synthesis

At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) (Judson et al., 2011) reveals a similar temporal expression pattern of MET as in rodents, with peak levels corresponding to the same periods detected in mice and rats

doi: 10.1002/hup.843

Data compiled by SHOOK Research LLC based on the time period from 6/30/23- 6/30/24 (Source: Forbes.com)