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According to the National Institutes of Health, oral B12 has a 1 to 2 percent absorption rate

Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified

**Neither peptide **is approved for human or veterinary use by the MHRA, FDA, or any other regulatory body

It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design