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CE was further optimized for highest signal abundance of each transition

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To provide a theoretical basis for the development of precision treatment strategies based on the regulation of TME, it will be necessary to further analyze the spatiotemporal dynamic regulatory network of Kla and confirm the therapeutic potential of targeting Kla metabolic enzymes (like LDHA) or epigenetic effectors through preclinical models

C.HelenoS.BarrosL.MartinsA.Santos-BuelgaC.et al