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In H2O2-induced human corneal epithelial cells, esculetin (20-100 M) activates the Nrf2 signaling pathway, inducing the expression of multiple antioxidant genes, including HO-1, quinone 1 (NQO1), glutamate cysteine ligase modifier subunit (GCLM), SOD1 and SOD2, thereby inhibiting ROS generation and accumulation (37)

Gene expression profiling predicts clinical outcome of breast cancer

Oral supplementation is the most practical and well-evidenced approach for long-term use

However, a negative association between circulating IGF-1 levels and the hematocrit has been also observed in predialysis patients, suggesting that the presence of uremic inhibitors could impair the effects of IGF-1 on erythroid cell proliferation, which could be restored in patients undergoing hemodialysis.128 In renal transplant recipients, patients developing erythrocytosis have similar serum levels of IGF-1 and EPO than those without erythrocytosis