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The mechanisms through which BPC-157 may support disc healing are multiple and interconnected

doi: 10.1038/mi.2017.73

Research protocols must account for potential beneficial roles of some senescent cells in wound healing and immune responses, requiring careful consideration of administration timing and duration in experimental designs

Several novel therapeutic strategies are in various stages of development, including apical sodium-dependent bile acid transporter and ileal bile acid transporter inhibitors, integrin inhibitors, peroxisome proliferator-activated receptor agonists, CCL24 blockers, recombinant FGF19, CCR2/CCR5 inhibitors, farnesoid X receptor bile acid receptor agonists, and nor-ursodeoxycholic acid