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Preclinical research efforts should also prioritize the development of patient-derived 3D tumor organoids and xenograft models that faithfully recapitulate CSC heterogeneity and therapy resistance

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Available treatments such as levodopa, dopamine agonists and monoamine oxidase B inhibitors offer only symptomatic relief however, they do not treat the underlying neurodegeneration, emphasising the need for neuroprotective management

Glutathione + Vitamin C supplementation helps in protecting the cells and tissues from damage and reduces oxidative stress