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Description
Symptoms range from those of alcoholic hepatitis to the complications of end-stage liver disease, such as portal hypertension (often with esophageal varices and upper gastrointestinal bleeding, splenomegaly, ascites, and portosystemic encephalopathy)

[DOI] [PubMed] [Google Scholar] 96.Plastira I, Bernhart E, Joshi L, Koyani CN, Strohmaier H, Reicher H, Malle E, Sattler W

Too much histamine there can be detrimental, and people with chronic heart failure have higher average plasma histamine levels
10.1073/pnas.79.6.1889 113 SenatorG
