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Although the majority of TBI patients return to premorbid baseline, a subset of patient can develop persistent and often debilitating neurocognitive and behavioral changes

For example, the inhibition of neutrophil elastases and serine proteases, which target the epithelium and its underlying support structure, has demonstrated a restorative effect on barrier permeability and intestinal inflammation [107]

doi: 10.1021/pr500782g 104 OttasAFishmanDOkasTLKingoKSoometsU

In vivo experiments indicated that it decreases ROS accumulation, inflammatory M1 macrophages, matrix degradation, and neovascularization, significantly improving IDD pathology