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For example, it has been reported that the plasma concentration of endoxifen in breast cancer patients is 6-fold higher than that of 4-OHT (Stearns et al ., 2003)

tested the administration of Lacticaseibacillus rhamnosus GG (LGG) and polymannuronic acid (PM) either alone or in combination (PM + LGG) in MPTP mice ( 2.1.6 Fecal microbiota transplantation (FMT) Fecal microbiota transplantation (FMT) is a procedure that consists in the transplantation of a gut microbiota extract, obtained from the feces of a healthy donor, into the GI tract of a recipient ( Clostridium difficile infection, ulcerative colitis, and others) because of its capacity to thoroughly and extensively regenerate gut microbiota, modifying intestinal microbial diversity and restoring atypical intestinal flora ( al ., FMT significantly mitigated gut dysbiosis and reduced microglia and astrocyte activation, thus suggesting a significant neuroprotective effect ( 2.2 Clinical evidence 2.2.1 Dietary interventions Among the numerous dietary regimens, the mediterranean diet (MD) is recognized as a dietary model able to improve health in several disorders, including cardiovascular diseases, cancer, and metabolic syndrome in both Mediterranean and non-Mediterranean populations ( Olea europaea L .) oil, containing monounsaturated fatty acids, which possesses antioxidant activity and can reduce -synuclein aggregation ( 2.2.2 Prebiotics The use of prebiotics in PD patients has been demonstrated to improve GI peristalsis, enhance immunological function, and alleviate constipation

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