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Description
Since B 12 deficiency results in MMA accumulation before B 12 reduction is seen in the serum [132], methylmalonic acid is a better indicator and preferred marker reflecting B 12 status before B 12 deficiency appears [120]

Options include higher dosing to finish faster, freezing portions (accepting some potency loss), or accepting the waste as acceptable cost of the protocol

Importantly, PKD activity was almost completely abolished in PKD3-deficient mice (Fig 4F)

This meeting is about whether certain bulk drug substances should be recommended for inclusion on the 503A Bulks List, which relates to compounding
