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Isoforms Nox1, Nox2, and Nox4 are involved in pain processing and several studies point to their functional role on the pathophysiology of NP [32]

[DOI] [Google Scholar] 147.Piotrowsky A., Burkard M., Hammerschmidt K., Ruple H.K., Nonnenmacher P., Schumacher M., Leischner C., Berchtold S., Marongiu L., Kufer T.A., et al

doi: 10.1183/09031936.06.00130004 88 LeeKSParkSJKimSRMinKHLeeKYChoeYHet al

632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway