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Description
In metastatic melanoma treatments, such as adoptive cell transfer therapies, initial remission can be followed by relapse due to melanoma cell dedifferentiation influenced by proinflammatory cytokines such as TNF- within the tumor microenvironment, facilitating immune evasion through antigen loss (67)
At present, research on ferroptosis is still in its infancy
Following tendon injury, HMGB1 release from necrotic cells is a primary pathway for NLRP3 activation, stimulating the assembly and activation of the NLRP3 inflammasome (137)
doi: 10.1038/labinvest.2016.116 30 YuCLYuHSSunKHHsiehSCTsaiCY
