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Additionally, proteomic studies have revealed altered protein levels in PD brain tissue, including an increased abundance of alpha-synuclein, which plays a central role in Lewy body and Lewy neurites formation as a hallmark pathological feature of PD 5
They found the levels of lipoperoxide, hydroperoxide, and conjugated diene in platelets were significantly higher in the early stage and positively correlated with the NIH Stroke Scale/Score (NIHSS)
As shown in Figure 2A and Online Supplementary Figure S2 , GATA1 was the transcription factor most significantly decreased after knockdown of USP7, although KLF1 levels also decreased
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