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Although benefits of mRNA CTNS delivery are mutation-independent, efficient delivery to kidney cells and expression of the mRNA remain difficult [155, 157]

We hypothesized that the results of the experiment are affected by multiple factors, such as drug batch, cell state, culture conditions, laboratory environment and other comprehensive factors, which lead different research groups to obtain different results

The peptide enters general circulation intact, or at least as intact as it was when it crossed the sublingual membrane

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Witschi A., Reddy S., Stofer B., Lauterburg B.H