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456,457 The ATF6 pathway The third arm of the UPR is perhaps also the least complex, as only one proteinthe transcription factor ATF6takes on both the sensor and effector roles

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimers disease

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