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5.1 Preventive antioxidants ROS such as OH, O2, and H 2 O 2 are generated irreversibly during the process of metabolism

oxidative stress, complement system, fibrosis) might be a promising therapeutic strategy to improve the quality of various donor organs and expand organ availability

Under normal physiological conditions the NO increase might be controlled by S-nitrosylation/glutathionylation of eNOS as an immediate response or by similar modification/activation of SERCA in steady-state regulation

Because high xCT levels are associated with poor prognosis in a number of cancer types, including GBM 66 and triple-negative breast cancer 67 , the xCT transporter has been suggested as a therapeutic target for cancer 6769