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Keywords: restless legs syndrome, vitamin D, genetics, proteomics, cardiovascular disease, inflammation, augmentation, dopamine, iron, endogenous opiate system, serotonin, adenosine, glutamate, vitamin D binding protein, cerebrovascular disease, calcium, phosphorus, parathyroid hormone Introduction Restless legs syndrome (RLS), or Willis-Ekbom Disease, is a sensorimotor neurological disorder characterized by the uncontrollable urge to move the legs, in response to uncomfortable or unpleasant sensations, that worsen during periods of rest or inactivity and later in the day or at night

Predetermined safety criteria were also met, including subjects baseline concerns regarding constipation, weight loss and blood lipid concentrations

[DOI] [PMC free article] [PubMed] [Google Scholar] Aman Y

One of the most prevalent characteristics of the cellular stress response is the production of heat shock proteins (HSPs) in response to stressors