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One potent strategy is to combine NRF2 inhibitors with cisplatin, which not only elevates intracellular ROS levels but also obscures the cancer cells ability to respond to oxidative stress [210,211,212]

NAC appears to exert its biological activity by acting as a precursor of glutathione, a ubiquitous compound with anti-oxidant properties that is involved in the metabolism of xenobiotics, signal transduction and gene expression, regulation of the cell cycle and apoptosis, and prostaglandin and leukotriene synthesis, among other processes [1, 2]

Among them, MSD-37 showed the highest inhibitory rate

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica