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Regulatory note: MOTS-c is not FDA-approved for human administration and is an unapproved research chemical
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Therefore, to prove that cotreatment with RAS blockade and direct FXa inhibition has additive or synergistic effects, basic animal studies and clinical research focusing on blood pressure and organ damage in patients treated with a combination treatment of ARB and Riv are needed (Fig
10.1371/journal.pone.0245323 156 GudnadottirU.KamauN.FornesR.NguyenM
