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PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

This study reports the discovery of essential components and mechanisms for ferroptosis regulation, as well as an intimate functional interplay between ferroptosis and cellular metabolism

Although HF development occurs predominantly during the embryonic life, over- and/or under-activation of signaling pathways, such as sonic hedgehog (shh), notch, TGF-, and Wnt/-catenin, which regulate epithelialmesenchymal interaction in HF, play roles in periodic regeneration of HF and, hence, hair cycling in adult [22]

doi: 10.1038/s41598-020-63345-5 99 XuWLiRSunY