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Lack of Creatine production results in prolonged lack of energy, with prolonged over-usage or underproduction eventually leading to the subject being chronically fatigued (CFS) Reduced production of Creatine has been associated with many conditions including dementia, Parkinson's disease, Autism, Chronic Fatigue Syndrome

Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain