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Creatine, a bioenergetic compound important in muscle metabolism, is found in meat sources and is endogenously synthesized from glycine, L-methionine and L-arginine in the liver, the kidney and the pancreas

It is an enzymatically generated signaling molecule derived from arginine that plays a crucial role in relaxing smooth muscle within blood vessel walls, leading to reduced blood pressure

Retinopathy and peripheral neuropathy are specific to long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiency [2, 4, 5]