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For further information on AXs role in the biological environment (e.g., plasma membrane and carrier proteins like HDL/LDL) and its induction of antioxidant enzymes, such as SODs, GSTs, GPXs, and Catalase, via the activation of the Nrf2/PGC-1 pathway, as well as its suppression of the production of pro-inflammatory cytokines by inhibiting the NFB or JAK/STAT pathway, please refer to the authors other comprehensive review (see Sections 1, 2.1 and 2.2 of [130])

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Combined glutathione S-transferase (GST)P1 (rs1138272 and rs1695) and GSTM3 genotypes showed cumulative risk regarding both occurrence and severity of COVID-19 (Coric et al., 2021)