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The Numbers Are Sobering: Patients with HH face a 20-fold increased risk of liver cancer, with an absolute risk of 6% among men and 1.5% among women at 10 years of follow-up A comparative study found that patients with HH had a relative risk of 1.8 for developing hepatocellular carcinoma and 1.8 for non-hepatic cancers compared to matched controls with non-iron-related chronic liver disease The incidence of hepatocellular carcinoma in individuals with hereditary hemochromatosis is 200 times greater than in the general population But the cancer risk extends beyond the liver

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Significant changes were observed between groups as the expression levels of dihydrolipoamide dehydrogenase (DLD), OGDH isoforms 1 and 2, succinate dehydrogenase B (SDHB), succinyl-CoA ligase ATP-forming subunit beta (SUCLA2), and succinyl-CoA ligase GTP-forming subunit beta (SUCLG2) enzymes were upregulated in the PHC of suicidal individuals (Fig