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Similarly, in breast PDOs, knocking out the tumor suppressor genes TP53 , PTEN , RB transcriptional corepressor 1 ( RB1 ) and NF1 , led to the development of estrogen receptor-positive luminal tumors upon transplantation in mice, which responded to endocrine therapy and chemotherapy (Dekkers et al., 2020)

Research involving multiple metabolic-, mitochondrial-, or stimulant-related compounds may warrant additional caution and individualized evaluation in experimental settings

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