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Amphetamines and methylphenidates are both associated with a crash in the afternoon or evening as a symptom of the dose wearing off, thought to be attributable to sudden imbalances in intracellular and synaptic dopamine after repeated stimulant exposure (Breggin, 1999)

GLP-1 peptides commonly cause: Significant nausea : Often severe enough to require dose titration over months

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