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The fate of new fosfamides in phase iii studies in advanced soft tissue sarcoma
The importance of NRF2 to cisplatin resistance has been demonstrated recently, and its overexpression has been correlated with higher resistance to several chemotherapeutic drugs in different types of cancer 17
NRF2/glutathione-mediated antioxidant defense pathway influences cisplatin resistance Another factor that could explain the different sensitivity between A549 and NCI H23 cell lines is an increased cisplatin detoxification, which can reduce cisplatin DNA damage, and as consequence, lower drug cytotoxicity
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